Diabetes, Genetics, Ethnicity, Oh My!
(Ivanhoe Newswire) - Researchers at the Stanford University School of Medicine Ethnic have found that a person's background plays a large role in how diabetes develops on a cellular level.
The researchers reanalyzed disease data to demonstrate that the physiological pathways to diabetes vary between Africa and East Asia and that those differences are reflected in part by genetic differences. They analyzed genome information of more than 1,000 people in 51 populations from around the world. They found a clear geographic pattern in the genetics behind type-2 diabetes. They concluded that the genetic risk is highest for Africans, while East Asians would appear to be protected, but East Asians are not necessarily at lower risk of diabetes than Africans.
The research also showed that because individuals from each ethnic group start at a different baseline position, they each reach diabetes in a different way: Africans through increased insulin resistance, and East Asians through lower insulin-secretion ability.
For more information go to: http://med.stanford.edu/ism/2013/may/diabetes_butte.html
SOURCE: PLoS Genetics, May, 2013
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