Medical Breakthroughs Reported by Click here to go to the homepage.
Be the First to Know. Click here to subscribe FREE!
Search Reports: Use quotation marks around your multi-word search terms in the box below to perform search of
Advances in health and medicine.Use " marks around search terms
What's New
News Flash
  Alternative Health
Asthma & Allergies
Breast Cancer
Cardiovascular Health
Children's Health
Dental Health
Fertility & Pregnancy
Men's Health
Mental Health
Multiple Sclerosis
Neurological Disorders
Nutrition & Wellness
Pet Health
Seniors' Health
Sports Medicine
Women's Health
Advances in health and medicine.
Click here to sign up for Medical Alerts!
Click below to access other news from Ivanhoe Broadcast News.
  Click here to get Ivanhoe's Medical Headline RSS feed Click here to listen to Ivanhoe's Medical Podcasts
Useful Links
Play It Again, Please
E-Mail a Friend
Order Books Online
Inside Science
Smart Woman
Advances in health and medicine.
Smart Woman Home
Click here to read the story
Click here to read the story
Click here to read the story
Smart Woman Home
Advances in health and medicine.
Click below to learn about Ivanhoe.
About Us
Contact Us
Ivanhoe FAQ
Our TV Partners
Travel Calendar
Advances in health and medicine.
Ivanhoe celebrates 20 years of medical news reporting reaching nearly 80 million TV households each week. Click here to learn more...
Advances in health and medicine.
Marjorie Bekaert Thomas
Advances in health and medicine.
Neurological Disorders Channel
Reported November 28, 2011

New Drug Targets Lou Gehrig’s Disease

By Ivanhoe Health Correspondent Melissa Colón

(Ivanhoe Newswire) – More than 90 percent of Lou Gehrig’s disease cases have no genetic cause or family history.  According to a recent study, two proteins conspire to promote a lethal neurological disease.

Since 2006, researchers have known that the protein TDP-43 is in involved in amyotrophic later sclerosis, ALS, also known as Lou Gehrig’s disease, a neurodegenerative disorder that results in progressing loss of motor function and ultimately death.

 “In this article, we report for the first time that TDP-43 interacts with and activates a protein called NF-kB p65 which is a key regulator for the synthesis of a number of factors associated with innate immunity and inflammation,” said Jean-Pierre Julien, PhD, Biochemistry, Senior Canada Research Chair in Neurodegeneration, Laval University, Quebec.

Furthermore, Jean-Pierre Julien and his colleagues at Laval University in Quebec found through examination of post-mortem spinal cord samples that the activation of the inflammatory protein NF-kB pathway was detected in ALS motor neurons and not only in immune cells.  Through the use of a mouse model of ALS, this discovery showed that an inhibitor of NF-kB pathway could weaken disease symptoms.

“The good news for ALS patients is that therapeutic interventions to target this pathway are conceivable. However, we must keep in mind that NF-kB inhibitors will have to be tested cautiously so as not to compromise our healthy—and necessary-- immune responses,” said Julien.

One of the goals of Julien and his colleagues will be to develop a drug treatment that can specifically target the interaction between TDP-43 andNF-kB p65.

SOURCE: Jean-Pierre Julien, Interviewed November 16, 2011




Related Articles in Latest Medical News:

[ Back to Neurological Disorders Channel Home ]

Stay up to date on Neurological Disorders. We can notify you every time there is a medical breakthrough. Click here to sign up.
Most Recent Videos

Follow Us On:

Click here to go to Ivanhoe's Twitter page Click here to go to Ivanhoe's Facebook page Click here to go to Ivanhoe's YouTube page

Home | What's New | News Flash | Search/Latest Medical News | E-Mail Medical Alerts!
Ivanhoe FAQ | Privacy Policy | Our TV Partners | Awards | Useful Links | Play It Again, Please
RSS Feeds | Advertising/Sponsorships | Content Syndication | Reprints

Advances in health and medicine.
Copyright © 2016 Ivanhoe Broadcast News, Inc.
2745 West Fairbanks Avenue
Winter Park, Florida 32789
(407) 740-0789

P.O. Box 865
Orlando, Florida 32802

Premium Content in Latest Medical News Denotes Premium Content in Latest Medical News