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Cancer Channel
Reported May 6, 2010

Easier Prep For Colonoscopy

(Ivanhoe Newswire) -- There may be a better way for patients to prep for colonoscopy procedures so they no longer need to drink a gallon of prescribed fluids the night before the procedure.

Researchers at Henry Ford Hospital, Detroit, found that as part of the colonoscopy prep, patients who took an FDA-approved pill for chronic constipation only needed to drink half of the liquid previously required to cleanse the bowels.

While the combination did not improve polyp detection during the colonoscopy, researchers say it did lead to improved bowel preparation quality and was better tolerated by patients than the liquid mix of polyethylene glycol (PEG) and electrolytes alone.

"Most people say they don't want to have a colonoscopy because they find the preparation intolerable," lead author Chetan Pai, D.O., a Henry Ford Hospital gastroenterologist, was quoted as saying.

To test the effectiveness of lubiprostone as part of colonoscopy prep, Henry Ford conducted a randomized, double blind and placebo-controlled study of 126 patients. Researchers looked at the tolerability of the combination of lubiprostone and electrolytes, as well as electrolytes alone, and whether it was possible to reduce the volume of electrolytes required for colon cleansing.

"If physicians are able to offer a better way to prep," Dr. Pai said, "I think this will encourage more people to get the colonoscopies that may save their lives."

SOURCE: Presented at Digestive Diseases Week conference, New Orleans, May 2, 2010


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